Villa Manos is located near the traditional village of Karterados which is walking distance from the capital Fira on the way to the beaches. Take the road from Fira to Karterados and the hotel is behind Alpfa supermarket.
The hotel is 1.5km from the airport and 12km from the port.
There is a bus stop right outside the hotel.
The hotel also provides free transfers from the airport & port to the hotel.